Two SUVs and a sedan, not real comparable vehicles. First, you need to decide whether you want a SUV or sedan.
If a sedan, then the Lexus IS. 350 has more power and is a tad bigger than a 250, also a little more expensive. 250 is available w/ AWD (350 isn't). IS-F is a great vehicle of course, but also twice the price of anything else listed, so I'm assuming probably not that.
For the SUVs, between the MDX and Q5, I personally like the Q5, but I like Audis too......
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