Anything is possible if you have the right funds to do it. Although I don't think a targa top is ideal for a 2000 Accord coupe, I'm sure it can be done and has been done! I own the same car and just with the back seats being there, I think it would look kinda weird. It looks great on the CRX and NSX, which have no back seats. I would suggest really thinking about it before taking on such a task. Once it's done, it will be hard to fix if you hate it or it doesn't turn out the way you want it to.Suggestions would be maybe going to a sunroof place and checking with them. They may have some options for something other than a conventional sunroof. Maybe a much larger sunroof if you are interested in getting some sun. Just don't do a California top... yuck.