You asked in the Acura section, so of course it will be biased. Hopefully I won't get any thumbs down for this one...It depends what are you going for. The TL, Touring Luxury is meant towards the driver who is looking more towards luxury with the occasional dap of performance. I own a TL with Navi, and all the technology in the car certainly is good, especially the voice commands. While the IS is more sporty, despite having less horsepower, 205 vs 270, the IS is a more rewarding drive. It is rwd, so it's more "fun" to toss around. I use to own an Infiniti G35 coupe, and I didn't think I would miss the rwd that much, but I did.Both are fine cars, I would personally for the IS250.