short answer... no.... and the missfire is not from the plugsi have been an auto tech for over 10 years and have never once put anti seize or dialectric grease on them, and i have never had a seized spark plug cause by me, when you have a service done on your vehicle they remove the spark plugs, or at least supose to, this breaks the carbon ring that has built up on the spark plug. auto zone/ advanced or any other automotive store sells you that stuff because it makes them money kinda like the little felt rings they sell you for a battery. My rule of thumb is if the factory didn't do it i won't either